Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions
نویسندگان
چکیده
Artemisia herba-alba Asso. is a shrub commonly encountered in Morocco. It is used in traditional medicine for treating intestinal disorders. The essential oil extracted from the plant's aerial parts reversibly relaxed the spontaneous tonus of the rabbit jejunum in a reversible concentration dependent manner with an IC(50) value of 97.33 ± 2.59 ng/ml and reversed the tonic contraction of rat jejunum induced by 75 mM KCl and 10(-6) M carbachol with IC(50) values of 115.5 ± 3.05 and 119.4 ± 20.86 ng/ml, respectively. The pre-treatment of the latter isolated intestine with this essential oil produced a dose-dependent shift of the Ca(++) and CCh dose-response curve to the right, with suppression of the maximal effect, similar to the non-competitive antagonist effect on muscarinic receptors and calcium channel, respectively.
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Because of application of “Artemisia” in traditional medicine, many species of this genus have been surveyed by phytochemists and pharmacologists. On the other hand, many species in compositeae family have been found that have effective ingredients in medicinal projects. One of iranian species investigated previously is “Artemisia aucheri” which have six highly oxygenated monoterpenes. By using...
متن کاملConstituents of the essential oil of Artemisia herba alba in Kashan area
Because of application of “Artemisia” in traditional medicine, many species of this genus have been surveyed by phytochemists and pharmacologists. On the other hand, many species in compositeae family have been found that have effective ingredients in medicinal projects. One of iranian species investigated previously is “Artemisia aucheri” which have six highly oxygenated monoterpenes. By using...
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